hippuryl-L-histidyl-L-leucine

HCID 94418CAS 31373-65-6
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Basic information

Standard SMILES
CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)c1ccccc1)C(=O)O
InChIKey
AAXWBCKQYLBQKY-IRXDYDNUSA-N
Molecular formula
C21H27N5O5
Average molar mass
429.5 g/mol
Monoisotopic mass
429.20121896

Overview

synthetic substrate for angiotensin converting enzyme; used in affinity chromatography

Names & identifiers

Preferred name
hippuryl-L-histidyl-L-leucine
IUPAC
(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid
English name
Hippuryl-His-Leu
Molecular formula
C21H27N5O5
Molecular weight
429.47

Names & synonyms

31373-65-6Hippuryl-histidyl-leucineHippuryl-L-histidyl-L-leucineBz-Gly-His-LeuHip-His-Leubenzoyl-glycyl-histidyl-leucineN-(N-(N-benzoylglycyl)-L-histidinyl)-L-leucinehippuryl-His-LeuRefChem:146465250-597-9Hippuryl-His-Leu-OHBz-Gly-His-Leu-OH
Show more names
H-HIP-HIS-LEU-OHBENZOYL-GLY-HIS-LEUHIPPURYL-HIS-LEU USP/EP/BP
(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acidbenzoylglycyl-L-histidyl-L-leucine(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid(2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-[2-(phenylformamido)acetamido]propanamido]-4-methylpentanoic acidN-Benzoyl-Gly-L-His-L-Leu-OHDTXSID30953414EINECS 250-597-9MFCD00005205

Database identifiers

CAS
31373-65-6
PubChem CID
94418
DTXSID
DTXSID30953414
EC Number
250-597-9
Nikkaji
J278.101H

Properties

Computed structural properties

XLogP
1.4
Topological polar surface area
153 Ų
Hydrogen bond donors
5
Hydrogen bond acceptors
6
Rotatable bonds
11
Heavy atoms
31

Physicochemical properties

Boiling point
912.4 · 912.4±65.0 °C(Predicted)
Density
1.283 · 1.283±0.06 g/cm3(Predicted)
storage temp.
20 °C · −20°C
solubility
50 mg/mL, · acetic acid: 50 mg/mL, clear, colorless
form
powder
pka
3.26 · 3.26±0.10(Predicted)

Safety & regulation

Safety data

F
10-21
wgk
3
Signal word
Warning
Symbol(GHS)
GHS07
Hazard statements
H302-H315-H319-H335
Precautionary statements
P280-P305+P351+P338

Chemistry & industry

Applications

UsesHippuryl-His-Leu-OH is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection[1][2][3].

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
南京昱盛康生物科技有限公司13327808530 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]

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