HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenediamine Dihydrochloride
ETHYLENEDIAMINE 2HCL · ETHYLENEDIAMMONIUM DICHLORIDE · Ethane-1,2-diamine dihydrochloride · Ethylenediaminehydrochloride · 1,2-DIAMINOETHANE DIHYDROCHLORIDE · chlor-ethamine · Ethylenediamine dihy · enediamine dihydrochL
Identifiers & Physical Properties
| CAS No. | 333-18-6 |
|---|---|
| Molecular formula | C2H10Cl2N2 |
| Average molar mass | 133.02 g/mol |
| Monoisotopic mass | 132.0221037 g/mol |
| SMILES | Cl.Cl.NCCN |
| InChIKey | OHHBFEVZJLBKEH-UHFFFAOYSA-N |
| PubChem CID | 9521 |
| ChEBI | CHEBI:53626 |
| EC No. | 206-369-6 |
| DTXSID | DTXSID5043920 |
Chemical & Physical Properties
| Topological polar surface area | 52 |
|---|---|
| Hydrogen bond donors | 4 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 1 |
| Heavy atoms | 6 |
| Formal charge | 0 |
| Complexity | 6 |
| Physical Description | White crystalline solidHygroscopic[Sigma-Aldrich MSDS] |
| Melting point | >300 °C(lit.) |
| Density | 1.46 g/cm3 |
| Bulk density | 650kg/m3 |
| Storage conditions | Store below +30°C. |
| Solubility | water: soluble100mg/mL, clear, colorless to very faintly yellow300 g/L (20 ºC) |
| Physical state | Crystalline Powder |
| Color | White to off-white |
| pH | 5 (100g/l, H2O, 20℃) |
| Sensitivity | Hygroscopic |
| BRN | 3665235 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C2H8N2.2ClH/c3-1-2-4/h1-4H22*1H |
| InChIKey | OHHBFEVZJLBKEH-UHFFFAOYSA-N |
| SMILES | C(N)CN.Cl.Cl |
| CAS DataBase Reference | 333-18-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 91WQV43244 |
| EPA Substance Registry System | Ethylenediamine dihydrochloride (333-18-6) |
| UNSPSC Code | 12352107 |
| NACRES | NA.22 |
| GHS pictogram | GHS07,GHS08 |
| Signal word | Danger |
| GHS hazard statements | H302-H315-H317-H319-H334-H335 |
| GHS precautionary statements | P261-P280-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338 |
| Hazard symbols | Xn |
| Risk statements (R) | 22-36/37/38-42/43 |
| Safety statements (S) | 22-26-36/37-45 |
| Water hazard class (WGK) | 2 |
| RTECS number | KV3850000 |
| TSCA inventory status | TSCA listed |
| Customs code | 29212100 |
| Storage class | 11 - Combustible Solids |
| Hazard class | Acute Tox. 4 OralEye Irrit. 2Resp. Sens. 1Skin Irrit. 2Skin Sens. 1STOT SE 3 |
| Toxicity | LD50 orally in Rabbit: 3250 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
Safety & Regulations
| GHS classification | DangerH302 (94.4%): Harmful if swallowed [Warning Acute toxicity, oral]H315 (93%): Causes skin irritation [Warning Skin corrosion/irritation]H317 (93%): May cause an allergic skin reaction [Warning Sensitization, Skin]H319 (93%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H334 (88.7%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H335 (88.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P233, P260, P261, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 71 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatory information | Chemical: 1,2-Ethanediamine, dihydrochlorideEthylenediammonium dichloride: Does not have an individual approval but may be used under an appropriate group standard |
| Hazards summary | Causes allergic dermatitis in 48-hr constant dermal studies of humans[RTECS] A skin and strong eye irritantMay cause skin and respiratory sensitizationHarmful by ingestionReproductive and developmental toxicity observed in experimental animals[Sigma-Aldrich MSDS] See Ethylenediamine. |
| Hazard Classes and Categories | Acute Tox. 4 (94.4%)Skin Irrit. 2 (93%)Skin Sens. 1 (93%)Eye Irrit. 2A (93%)Resp. Sens. 1 (88.7%)STOT SE 3 (88.7%) |
| Protective Action Criteria (PAC) | 2.7 [mg/m3]29 [mg/m3]180 [mg/m3] |
| Adverse effects | Skin Sensitizer - An agent that can induce an allergic reaction in the skin.Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents. |
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | KV3850000 |
| Customs code | 29212100 |
| Toxicity | LD50 orally in Rabbit: 3250 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Risk statements (R) | 22-36/37/38-42/43 |
| Signal word | Danger |
| GHS pictogram | GHS07,GHS08 |
| Hazard symbols | Xn |
| Safety statements (S) | 22-26-36/37-45 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H302-H315-H317-H319-H334-H335 |
| Hazard class | Acute Tox. 4 OralEye Irrit. 2Resp. Sens. 1Skin Irrit. 2Skin Sens. 1STOT SE 3 |
| GHS precautionary statements | P261-P280-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338 |
Applications & Uses
Uses
Ethylenediamine dihydrochloride is used as stabilizer in steroid creams and rubber latex; inhibitor in antifreeze solutions and cooling fluids; in floor-polish remover; in nystatin cream and aminophylline; epoxy-curing agent; accelerator in color development baths in photography; in veterinary preparations; in electroplating and electrophoretic gels, dyes, fungicides, insecticides, synthetic waxes, textile lubricants, and eye and nose drops; solvent for casein, albumin, shellac.
Uses
Ethylenediamine dihydrochloride was used in modified ethylenediamine condensation method for fluorimetric determination of catecholamines. It was used to investigate the luminescence properties of complexes of EuIII and TbIII with ethylenediamine. It was used in the synthesis of 1,3,5-tris(4,5-dihydro-1H-imidazol-2-yl)benzene.