Basic information
- CAS
334-50-9- Standard SMILES
Cl.Cl.Cl.NCCCCNCCCN- InChIKey
LCNBIHVSOPXFMR-UHFFFAOYSA-N- Molecular formula
- C7H22Cl3N3
- Average molar mass
- 254.6 g/mol
- Monoisotopic mass
- 253.087931
Overview
Spermidine trihydrochloride is an organic molecular entity. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is functionally related to a spermidine.
Names & identifiers
- Preferred name
- Spermidine trihydrochloride
- IUPAC
- N'-(3-aminopropyl)butane-1,4-diamine;trihydrochloride
- English name
- Spermidine trihydrochloride
- Molecular formula
- C7H22Cl3N3
- Molecular weight
- 254.63
Names & synonyms
Spermidine trihydrochloride334-50-9Spermidine hydrochlorideSpermidine HClN-(3-Aminopropyl)-1,4-butanediamine trihydrochlorideEINECS 206-379-0NSC 5283991,4-BUTANEDIAMINE, N-(3-AMINOPROPYL)-, TRIHYDROCHLORIDE1O14BED3981,4-Butanediamine, N-(3-aminopropyl), hydrochloride4-Azoniaoctamethylenediammonium trichlorideNSC-528399
Show more names
SPERMIDINE 3HCLN-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDESpermidie 3HCLSPD·3HClSperMidine triSPERMIDINE 3HCSperpmidine HCLSpermidine 3HCl>98%
SPERMIDINE TRIHYDROCHLORIDE [MI]1,4-Butanediamine, N1-(3-aminopropyl)-, hydrochloride (1:3)RefChem:888501SPERMIDINE HCL [INCI]4Azoniaoctamethylenediammonium trichlorideN(3Aminopropyl)1,4butanediamine trihydrochloride1,4Butanediamine, N(3aminopropyl), hydrochloride1,4Butanediamine, N(3aminopropyl), trihydrochloride
Database identifiers
Properties
Computed structural properties
- Topological polar surface area
- 64.1 Ų
- Hydrogen bond donors
- 6
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 7
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 56.8
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Biochemical Research
Physical DescriptionSolid; [Merck Index] White hygroscopic powder; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 257 · 257-259 °C(lit.)
- storage temp.
- room temp
- solubility
- 2 O: · H2O: 1 M at 20 °C, clear, colorless
- form
- Crystalline Powder
- color
- White
- PH
- 3 · 3.0-6.0 (25℃, 1M in H2O)
- biological source
- microbialsynthetic
- Water Solubility
- Soluble in water (100 mg/ml), and ethanol.
- λmax
- 260 nm · λ: 260 nm Amax: 0.2λ: 280 nm Amax: 0.1
- BRN
- 3552356 · 3552356
- Cosmetics Ingredients Functions
- HAIR CONDITIONING
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazards SummaryCauses convulsions in acute intraperitoneal studies of rats and mice; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- F
- 3-10
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- EJ7023000
- hs_code
- 29212900
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
Chemistry & industry
Uses & manufacturing
UsesFound widely in nature and essential for tissue growth; Used as a tool in biochemical research; [Merck Index]
General Manufacturing Information1,4-Butanediamine, N1-(3-aminopropyl)-, hydrochloride (1:3): ACTIVE
Applications
DescriptionSpermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.
UsesSpermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.
General DescriptionSpermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.
Suppliers100 total
山西玉宁生物科技有限公司13623677056 · [email protected]
山东科立康药业有限公司053-88113608 17854192669 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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