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Basic information
- CAS
164301-51-3- Standard SMILES
C/C(=N\N=C(N)N)c1cc(NC(=O)CCCCCCCCC(=O)Nc2cc(/C(C)=N/N=C(N)N)cc(/C(C)=N/N=C(N)N)c2)cc(/C(C)=N/N=C(N)N)c1.Cl.Cl.Cl.Cl- InChIKey
MAHASPGBAIQZLY-RTQZJKMDSA-N- Molecular formula
- C34H56Cl4N18O2
- Average molar mass
- 890.758 g/mol
- Monoisotopic mass
- 888.35877375
Names & identifiers
- Preferred name
- Semapimod hydrochloride
- English name
- CNI-1493
- Molecular formula
- C34H53ClN18O2
- Molecular weight
- 781.37
Names & synonyms
Semapimod 4HClSemapimod hydrochlorideCPSI-2364 tetrahydrochlorideSeMapiMod (tetrahydrochloride)Semapimod (tetrahydrochloride)(CNI-1493)N1,N10-Bis(3,5-bis(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide tetrahydrochlorideN,N'-bis[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide,tetrahydrochlorideN,N'-bis[3-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]-5-[(Z)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide:tetrahydrochloride
Database identifiers
- CAS
164301-51-3- PubChem CID
- 9554199
- DTXSID
DTXSID301028119- UNII
- A16WYQ522A
Properties
Physicochemical properties
- storage temp.
- -20 °C, · -20°C, protect from light
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to yellow
- FDA UNII
- 16 WYQ522A · A16WYQ522A
Chemistry & industry
Applications
UsesSemapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
Suppliers14 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北魏氏化学试剂股份有限公司027-59102966 18717199209 · [email protected]
InvivoChem中国13549236410 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
斯派螺（武汉）药物研发有限公司[email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
上海一飞生物科技有限公司
Related reactions
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Compound notes
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