4-Fluorobenzyl chloride

HCID 9602
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Substructure searchFind similar structures

Basic information

CAS
352-11-4
Standard SMILES
Fc1ccc(CCl)cc1
InChIKey
IZXWCDITFDNEBY-UHFFFAOYSA-N
Molecular formula
C7H6ClF
Average molar mass
144.57 g/mol
Monoisotopic mass
144.014206

Names & identifiers

Preferred name
4-Fluorobenzyl chloride
IUPAC
1-(chloromethyl)-4-fluorobenzene
English name
4-Fluorobenzyl chloride
Molecular formula
C7H6ClF
Molecular weight
144.57

Names & synonyms

4-Fluorobenzyl chloride352-11-4Benzene, 1-(chloromethyl)-4-fluoro-DTXSID70598504FBCl cpdRefChem:562388DTXCID1038955206-516-41-(Chloromethyl)-4-fluorobenzeneP-FLUOROBENZYL CHLORIDEalpha-Chloro-p-fluorotoluene1-Chloromethyl-4-fluoro-benzene
Show more names
JACS-352-11-4Benzyl for CFCsAKOS BBS-00003856p-Fluorbenzylchloridalpha-Chloro-p-fluorFluorobenzyl chloridp-fluorochlorobenzyl-Chloro-p-fluorotoluene
1-Chloromethyl-4-fluorobenzene4-fluorobenzylchlorideMFCD00000913alpha-Chloro-4-fluorotoluene4-(chloromethyl)-1-fluorobenzeneToluene, .alpha.-chloro-p-fluoro-4-Fluorobenzyl--d4 ChlorideEINECS 206-516-4

Database identifiers

CAS
352-11-4
PubChem CID
9602
DTXSID
DTXSID7059850
EC Number
206-516-4
Nikkaji
J36A

Properties

Computed structural properties

XLogP
2.6
Topological polar surface area
0 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
1
Rotatable bonds
1
Heavy atoms
9

Experimental & physicochemical properties

Vapor Pressure0.99 [mmHg]
Physical DescriptionClear colorless liquid; [Sigma-Aldrich MSDS]
Kovats Retention Index989.6；989.6

Physicochemical properties

Melting point
-18 °C · -18 °C
Boiling point
82 °C26 · 82 °C26 mm Hg(lit.)
Density
1.207 g/mL · 1.207 g/mL at 25 °C(lit.)
refractive index
20 · n20/D 1.513(lit.)
Flash point
141 °F · 141 °F
storage temp.
30 °C · Store below +30°C.

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H226 (19.7%): Flammable liquid and vapor [Warning Flammable liquids]；H301 (18%): Toxic if swallowed [Danger Acute toxicity, oral]；H302 (14.8%): Harmful if swallowed [Warning Acute toxicity, oral]；H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P301+P316, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 61 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information4-Fluorobenzyl chloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryCauses burns and lachrymation; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Sigma-Aldrich MSDS] See 2-Chlorobenzyl chloride.
Hazard Classes and CategoriesFlam. Liq. 3 (19.7%)；Acute Tox. 3 (18%)；Acute Tox. 4 (14.8%)；Skin Corr. 1B (100%)

Toxicology

Adverse EffectsDermatotoxin - Skin burns.；Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Regulatory information

Regulatory Information4-Fluorobenzyl chloride: Does not have an individual approval but may be used under an appropriate group standard

Safety data

F
19
PPE
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk
2
tsca
TSCA listed
ridadr
UN 2920 8/PG 2
hs_code
29036990

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationBenzene, 1-(chloromethyl)-4-fluoro-: ACTIVE

Applications

Usesp-Fluorobenzyl Chloride is a chemical intermediate in the synthesis of various pharmaceutical and agricultural goods.

Upstream & downstream products

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Related reactions

291 records
New reaction record

Compound notes

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