2-Fluoro-6-methylpyridine
6-FLUORO-2-PICOLINE · 6-me · 2-FLUORO-6-PICOLINE · 2-FLUORO-6-METHYLPYRIDINE · 6-methyl-2-fluoropyridine · Pyridine, 2-fluoro-6-methyl- · 2-Fluoro-6-methylpyridine98% · 2-Fluoro-6-methylpyridine>2-FLUORO-6-METHYLPYRIDINE 98%
Identifiers & Physical Properties
| CAS No. | 407-22-7 |
|---|---|
| Molecular formula | C6H6FN |
| Average molar mass | 111.12 g/mol |
| Monoisotopic mass | 111.04842741 g/mol |
| SMILES | Cc1cccc(F)n1 |
| InChIKey | UDMNVTJFUISBFD-UHFFFAOYSA-N |
| PubChem CID | 96090 |
| EC No. | 206-980-8 |
| DTXSID | DTXSID50193673 |
Chemical & Physical Properties
| XLogP | 1.2 |
|---|---|
| Topological polar surface area | 12.9 |
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 0 |
| Heavy atoms | 8 |
| Formal charge | 0 |
| Complexity | 74.9 |
| Boiling point | 140-141 °C (lit.) |
| Density | 1.077 g/mL at 25 °C (lit.) |
| Refractive index | n20/D 1.47(lit.) |
| Flash point | 152 °F |
| Storage conditions | Keep in dark place,Sealed in dry,Room Temperature |
| Physical state | clear liquid |
| pKa (acidity coefficient) | 0.29±0.10(Predicted) |
| Color | Colorless to Light orange to Yellow |
| Specific gravity | 1.07 |
| BRN | 107084 |
| InChI | 1S/C6H6FN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3 |
| InChIKey | UDMNVTJFUISBFD-UHFFFAOYSA-N |
| SMILES | Cc1cccc(F)n1 |
| CAS DataBase Reference | 407-22-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Fluoro-6-methylpyridine(407-22-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Target organs | Respiratory system |
| Personal protective equipment (PPE) | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard symbols | Xi,F |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| UN transport number | 1993 |
| Water hazard class (WGK) | 3 |
| Hazard Note | Flammable/Irritant |
| Hazard class | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Customs code | 29333990 |
| Storage class | 10 - Combustible liquids |
Safety & Regulations
| GHS classification | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 50 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Personal protective equipment (PPE) | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Water hazard class (WGK) | 3 |
| UN transport number | 1993 |
| Customs code | 29333990 |
| Risk statements (R) | 36/37/38 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi,F |
| hazard_note | Flammable/Irritant |
| Safety statements (S) | 26-36 |
| Hazard class | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Storage class | 10 - Combustible liquids |
| Target organs | Respiratory system |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Applications & Uses
Uses
2-Fluoro-6-methylpyridine may be used in the preparation of:2-fluoro-6-pyridinecarboxylic acid2,2′-[1-(6-methylpyridin-2-yl)ethane-1,1-diyl]dipyridine2-fluoropyridine-6-aldoxime2-fluoro-6-(dibromomethyl)pyridine
General Description
2-Fluoro-6-methylpyridine, also known as 2-fluoro-6-picoline, can be prepared via diazotization of 2-amino-6-methylpyridine in hydrogen fluoride containing 40% pyridine solution. The effect of substituents on spectral properties of 2-fluoro-6-methylpyridine has been investigated based on 13C NMR, UV and IR spectral data.