Tetrahydropalmatine, (+)-
Basic information
- CAS
3520-14-7- Standard SMILES
COc1cc2c(cc1OC)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2- InChIKey
AEQDJSLRWYMAQI-QGZVFWFLSA-N- Molecular formula
- C21H25NO4
- Average molar mass
- 355.4 g/mol
- Monoisotopic mass
- 355.17835828
Overview
D-Tetrahydropalmatine is an alkaloid.
Names & identifiers
- Preferred name
- Tetrahydropalmatine, (+)-
- IUPAC
- (13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
- English name
- D-Tetrahydropalmatine
- Molecular formula
- C21H25NO4
- Molecular weight
- 355.43
Names & synonyms
D-Tetrahydropalmatine3520-14-7(+)-Tetrahydropalmatine(+)-(R)-Tetrahydropalmatine(+)-Corydalis BCorydalis alkaloid BTetrahydropalmatine, (+)-(+)-2,3,9,10-Tetramethoxyberbine7BLG4NXS54(13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline13abeta-Berbine, 2,3,9,10-tetramethoxy-DTXSID80359548
Show more names
d-TetrahydroD-TetrahydropalmatinD-TetrahydropalmitineRafoxanide Impurity 4(R)-TetrahydropalMatineD-Tetrahydropalmatine ,98%Dextral tetrahydropalMatine(+)-TetrahydropalMatine Alkaloid
6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aR)-(13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino(2,1-b)isoquinolineTetrahydropalmatine D-RefChem:1099695DTXCID10310602corydalis BTetrahydropalmatinTetrahydropalmatine D-form [MI]
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 3.2
- Topological polar surface area
- 40.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 475
Physicochemical properties
- Melting point
- 138 · 138-139 °C
- Boiling point
- 482.9 · 482.9±45.0 °C(Predicted)
- Density
- 1.23 · 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- pka
- 6.53 · 6.53±0.20(Predicted)
- color
- White to Pale Yellow
- FDA UNII
- 7 BLG4NXS54 · 7BLG4NXS54
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
UsesD-Tetrahydropalmatine is an alkaloid isolated from a traditional Chinese herb Rhizoma Corydalis (yanhusuo). D-Tetrahydropalmatine inhibits dopamine and serotonin uptake of synaptosomes in the rat brain. D-Tetrahydropalmatine also shows inhibitory effects on acetylcholinesterase and butyrylcholinesterase.
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Related reactions
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Compound notes
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