Basic information
- CAS
370-81-0- Standard SMILES
O=C(NN=C1CCCCC1)C(=O)NN=C1CCCCC1- InChIKey
DSRJIHMZAQEUJV-UHFFFAOYSA-N- Molecular formula
- C14H22N4O2
- Average molar mass
- 278.35 g/mol
- Monoisotopic mass
- 278.17427596
Overview
Cuprizon is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.
Names & identifiers
- Preferred name
- Cuprizone
- IUPAC
- N,N'-bis(cyclohexylideneamino)oxamide
- English name
- Bis(cyclohexanone)oxaldihydrazone
- Molecular formula
- C14H22N4O2
- Molecular weight
- 278.35
Names & synonyms
Cuprizone370-81-0CuprizaneEthanedioic acid, bis(cyclohexylidenehydrazide)Biscyclohexanone oxaldihydrazone5N16U7E0AOOxaldihydrazone, BiscyclohexanoneDTXSID30861909NSC-4283RefChem:388902DTXCID40810761206-729-2
Show more names
CUPRIZON 1CUPRIZON ICUPRIZONE ICUPFERAZONECuprizonl,98%oxaldihydrazoneOxalic acid bis
Bis(cyclohexanone)oxaldihydrazoneOxalic acid bis(cyclohexylidenehydrazide)CuprizonBiscyclohexanone oxalyldihydrazoneN,N'-bis(cyclohexylideneamino)oxamideNSC 4283Oxalic bis(cyclohexylidenehydrazide)MFCD00001659
Database identifiers
- CAS
370-81-0- PubChem CID
- 9723
- DTXSID
DTXSID30861909- ChEBI
CHEBI:177802- UNII
- 5N16U7E0AO
- EC Number
- 206-729-2
Properties
Computed structural properties
- XLogP
- 1.6
- Topological polar surface area
- 82.9 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 373
Physicochemical properties
- Melting point
- 210 · 210-214 °C(lit.)
- Boiling point
- 421.17 °C · 421.17°C (rough estimate)
- Density
- 1.0823 · 1.0823 (rough estimate)
- bulk density
- 150 kg/m3 · 150kg/m3
- refractive index
- 1.62 · 1.6200 (estimate)
- storage temp.
- 2 · 2-8°C
- solubility
- 50 mg/mL, · acetic acid: 50mg/mL, colorless to very faintly brown
- form
- Powder
- pka
- 10.78 · 10.78±0.20(Predicted)
- color
- White
- Water Solubility
- Soluble in alcohol. Insoluble in water.
- BRN
- 2388004 · 2388004
- InChI
- 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
- InChIKey
- DSRJIHMZAQEUJV-UHFFFAOYSA-N
- SMILES
- O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 22.2% (2 of 9) of reports.
Warning
H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 9 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Ethanedioic acid, bis(cyclohexylidenehydrazide)
Ethanedioic acid, bis(cyclohexylidenehydrazide): Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 4 (11.1%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- RO2520000
- hs_code
- 29280090
- risk_code
- 21/22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 24/25-2
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Uses & manufacturing
General Manufacturing InformationEthanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide): ACTIVE
Applications
UsesBis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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