Basic information
- Standard SMILES
Fc1ccccn1- InChIKey
MTAODLNXWYIKSO-UHFFFAOYSA-N- Molecular formula
- C5H4FN
- Average molar mass
- 97.09 g/mol
- Monoisotopic mass
- 97.03277735
Names & identifiers
- Preferred name
- 2-Fluoropyridine
- IUPAC
- 2-fluoropyridine
- English name
- 2-Fluoropyridine
- Molecular formula
- C5H4FN
- Molecular weight
- 97.09
Names & synonyms
2-Fluoropyridine372-48-5PYRIDINE, 2-FLUORO-WKQ4JPY48SAI3-28562NSC-5077DTXSID70190689RefChem:87187DTXCID60113180206-757-5Pyridine, fluoro-MFCD00006224
Show more names
2-CYANOPHENYLBORONIC ACID2-Fluoropyride2-Fluorpyridin2-fluoro-pyridin2-Fluoroypyridine2-Fluorpyridin CAS2-fluoride pyridine
o-fluoropyridineCCRIS 1725NSC 50772-Fluoropyridine; 2-Pyridyl Fluoride; NSC 5077;EINECS 206-757-5BRN 0001515fluoropyridine2Fluoropyridine
Database identifiers
- CAS
372-48-5- PubChem CID
- 9746
- DTXSID
DTXSID70190689- ChEMBL
CHEMBL1162360- UNII
- WKQ4JPY48S
- EC Number
- 206-757-5
- Nikkaji
- J43D
Properties
Computed structural properties
- XLogP
- 0.8
- Topological polar surface area
- 12.9 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 56
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Pyridines
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP0.84
Vapor Pressure26.6 [mmHg]
Physical DescriptionClear dark brown liquid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Boiling point
- 126 °C/753 · 126 °C/753 mmHg (lit.)
- Density
- 1.128 g/mL · 1.128 g/mL at 25 °C (lit.)
- refractive index
- 20 · n20/D 1.466(lit.)
- Flash point
- 83 °F · 83 °F
- storage temp.
- 2 · Inert atmosphere,2-8°C
- form
- Liquid
- pka
- -0.44 · -0.44(at 25℃)
- color
- Clear colorless to light yellow
- Specific Gravity
- 1.13 · 1.13
- Water Solubility
- Soluble in water.
- BRN
- 1515 · 1515
- Dielectric constant
- 37.29 · 37.289999999999999
- InChI
- InChI=1S/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H
- InChIKey
- MTAODLNXWYIKSO-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=CC=C1
- CAS DataBase Reference
- 372 · 372-48-5(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 4 JPY48S · WKQ4JPY48S
- NIST Chemistry Reference
- 2 · 2-Fluoropyridine(372-48-5)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 2 · GHS02,GHS07
- Signal word
- Warning
- Hazard statements
- 226 · H226-H315-H319-H335
- Precautionary statements
- 210 · P210-P302+P352-P305+P351+P338
- target organs
- Respiratory system
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- Hazard Codes
- Xi,F,Xn
- Risk Statements
- 10 · 10-36/37/38-20/21/22
- Safety Statements
- 26 · 26-36-36/37/39-16
- RIDADR
- 1993 · UN 1993 3/PG 3
- WGK Germany
- 3 · 3
- RTECS
- 3900000 · UT3900000
- Hazard Note
- Flammable/Irritant
- HazardClass
- 3 · 3
- PackingGroup
- III
- HS Code
- 29333999 · 29333999
- Storage Class
- 3 · 3 - Flammable liquids
- Hazard Classifications
- 2 Flam · Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3
- REACH Registrations
- Active
- Limited Quantities
- 5 L · 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Safety & regulation
GHS classification
GHS Classification
Warning
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 50 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information2-Fluoropyridine: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesFlam. Liq. 3 (100%)
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 3
- rtecs
- UT3900000
- ridadr
- UN 1993 3/PG 3
- hs_code
- 29333999
- risk_code
- 10-36/37/38-20/21/22
- Signal word
- Warning
- Symbol(GHS)
- GHS02,GHS07
- hazard_code
- Xi,F,Xn
- hazard_note
- Flammable/Irritant
- safety_code
- 26-36-36/37/39-16
- hazard_class
- 3
- Storage Class
- 3 - Flammable liquids
- packing_group
- III
- target organs
- Respiratory system
- Hazard statements
- H226-H315-H319-H335
- Limited Quantities
- 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
- REACH Registrations
- Active
- Hazard Classifications
- Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3
- Precautionary statements
- P210-P302+P352-P305+P351+P338
Chemistry & industry
Applications
Uses2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
Upstream & downstream products
Upstream raw materials
Downstream products
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