2-Fluoropyridine
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Basic information
- CAS
372-48-5- Standard SMILES
Fc1ccccn1- InChIKey
MTAODLNXWYIKSO-UHFFFAOYSA-N- Molecular formula
- C5H4FN
- Average molar mass
- 97.09 g/mol
- Monoisotopic mass
- 97.03277735
Names & identifiers
- Preferred name
- 2-Fluoropyridine
- IUPAC
- 2-fluoropyridine
- English name
- 2-Fluoropyridine
- Molecular formula
- C5H4FN
- Molecular weight
- 97.09
Names & synonyms
2-Fluoropyridine372-48-5PYRIDINE, 2-FLUORO-WKQ4JPY48SAI3-28562NSC-5077DTXSID70190689RefChem:87187DTXCID60113180206-757-5Pyridine, fluoro-MFCD00006224
Show more names
2-CYANOPHENYLBORONIC ACID2-Fluoropyride2-Fluorpyridin2-fluoro-pyridin2-Fluoroypyridine2-Fluorpyridin CAS2-fluoride pyridine
o-fluoropyridineCCRIS 1725NSC 50772-Fluoropyridine; 2-Pyridyl Fluoride; NSC 5077;EINECS 206-757-5BRN 0001515fluoropyridine2Fluoropyridine
Database identifiers
- CAS
372-48-5- PubChem CID
- 9746
- DTXSID
DTXSID70190689- ChEMBL
CHEMBL1162360- UNII
- WKQ4JPY48S
- EC Number
- 206-757-5
- Nikkaji
- J43D
Properties
Computed structural propertiesFilling in
- XLogP
- 0.8
- Topological polar surface area
- 12.9 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 56
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Pyridines
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP0.84
Vapor Pressure26.6 [mmHg]
Physical DescriptionClear dark brown liquid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Boiling point
- 126 °C/753 · 126 °C/753 mmHg (lit.)
- Density
- 1.128 g/mL · 1.128 g/mL at 25 °C (lit.)
- refractive index
- 20 · n20/D 1.466(lit.)
- Flash point
- 83 °F · 83 °F
- storage temp.
- 2 · Inert atmosphere,2-8°C
- form
- Liquid
- pka
- -0.44 · -0.44(at 25℃)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 50 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information2-Fluoropyridine: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesFlam. Liq. 3 (100%)
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 3
- rtecs
- UT3900000
- ridadr
- UN 1993 3/PG 3
- hs_code
- 29333999
- risk_code
- 10-36/37/38-20/21/22
- Signal word
- Warning
- Symbol(GHS)
- GHS02,GHS07
- hazard_code
- Xi,F,Xn
- hazard_note
- Flammable/Irritant
Chemistry & industry
Applications
Uses2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
366 records
Compound notes
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