1-(4-Chlorophenyl)piperazine

HCID 97478CAS 38212-33-8
Substructure searchFind similar structures

Basic information

Standard SMILES
Clc1ccc(N2CCNCC2)cc1
InChIKey
UNEIHNMKASENIG-UHFFFAOYSA-N
Molecular formula
C10H13ClN2
Average molar mass
196.67 g/mol
Monoisotopic mass
196.0767261

Overview

increases serotonin & decreases 5-hydroxyindoleacetic acid concentration in rat brain 6 hours after administration; RN given refers to parent cpd

Names & identifiers

Preferred name
1-(4-Chlorophenyl)piperazine
IUPAC
1-(4-chlorophenyl)piperazine
English name
1-(4-Chlorophenyl)piperazine
Molecular formula
C10H13ClN2
Molecular weight
196.68

Names & synonyms

1-(4-Chlorophenyl)piperazine38212-33-8Piperazine, 1-(4-chlorophenyl)-FMD47JE5C3NSC-1267081-(para-Chlorophenyl)piperazineDTXSID90191592RefChem:74469DTXCID30114083627-233-6para-chlorophenylpiperazine1-(4-chlorophenyl)-piperazine
Show more names
AKOS BBS-00003582TIMTEC-BB SBB003580RARECHEM AH CK 00721-(4-CHLORPHENYL)PIPERAZINE1-(4-Chlorophenyl)Piperazone4-(Piperazin-1-yl)chlorobenzene
MFCD000448231-(4-Chloro-phenyl)-piperazineCHEMBL114478(4-chlorophenyl)piperazine4-(4-chlorophenyl)piperazineNSC126708NSC 126708p-chlorophenylpiperazine

Database identifiers

CAS
38212-33-8
PubChem CID
97478
DTXSID
DTXSID90191592
ChEMBL
CHEMBL114478
UNII
FMD47JE5C3
EC Number
627-233-6
Nikkaji
J253.123B

Properties

Computed structural properties

XLogP
1.8
Topological polar surface area
15.3 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
1
Heavy atoms
13

Experimental & physicochemical properties

Drugs · 2 items

DEA NFLIS-Drug Category -> Piperazines (Hallucinogen)

Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds

Physicochemical properties

Melting point
76 · 76-79 °C
Boiling point
113 °C/0.27mm · 113°C/0.27mm
Density
1.1428 · 1.1428 (rough estimate)
refractive index
1.5749 · 1.5749 (estimate)
storage temp.
2 · Storage temp. 2-8°C
solubility
30 mg/ml; · DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Methanol: 1 mg/ml

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

F
10-34
PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
hs_code
29339900
risk_code
36/37/38
Signal word
Warning

Chemistry & industry

Applications

Uses1-(4-Chlorophenyl)piperazine is used as a 5-HT-1 serotonin receptor agonist. It is also used as a pharmaceutical intermediate.

Upstream & downstream products

Suppliers50 total

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
成都市久鼎化学技术有限公司18584079237 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海瀚麟生物科技有限公司183-0212-4410 18302124410 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

Related reactions

229 records
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Linked notes

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