Ethyl 7-benzoyl-3-(naphthalene-2-carbonyl)indolizine-1-carboxylate
Basic information
- CAS
374679-27-3- Standard SMILES
CCOC(=O)c1cc(C(=O)c2ccc3ccccc3c2)n2ccc(C(=O)c3ccccc3)cc12- InChIKey
OMNFLCJXENKOCL-UHFFFAOYSA-N- Molecular formula
- C29H21NO4
- Average molar mass
- 447.5 g/mol
- Monoisotopic mass
- 447.14705815
Names & identifiers
- Preferred name
- Ethyl 7-benzoyl-3-(naphthalene-2-carbonyl)indolizine-1-carboxylate
- IUPAC
- ethyl 7-benzoyl-3-(naphthalene-2-carbonyl)indolizine-1-carboxylate
- English name
- VEC 5
- Molecular formula
- C29H21NO4
- Molecular weight
- 447.49
Names & synonyms
VEC-5374679-27-3Vif-ElonginC interaction inhibitor 1Ethyl 7-benzoyl-3-(naphthalene-2-carbonyl)indolizine-1-carboxylate7-Benzoyl-3-(naphthalene-2-carbonyl)-indolizine-1-carboxylic acid ethyl esterorb1701488CHEMBL5440259SCHEMBL29766498GLXC-03122AKOS024285416DA-68547ST083671
Show more names
VEC5VEC 5
HY-120157CS-0077039T26316ethyl 3-(2-naphthylcarbonyl)-7-(phenylcarbonyl)indolizinecarboxylateETHYL 7-BENZOYL-3-(2-NAPHTHOYL)-1-INDOLIZINECARBOXYLATE
Database identifiers
- CAS
374679-27-3- PubChem CID
- 980299
- ChEMBL
CHEMBL5440259- EC Number
- 105-085-9
Properties
Computed structural properties
- XLogP
- 7
- Topological polar surface area
- 64.9 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 7
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 759
Chemistry & industry
Applications
DescriptionVEC-5 is a HIV-1 inhibitor. VEC5 have been evaluated for their inhibitory potential employing ligand receptor and protein-protein interactions studies. VEC 5 showed better interaction with Vif than RN18.
UsesVif-ElonginC interaction inhibitor 1 (compound VEC-5) is a potent Vif inhibitor. Vif-ElonginC interaction inhibitor 1 can restrict HIV-1 in Vif-nonpermissive cells. Vif-ElonginC interaction inhibitor 1 can protect A3G, APOBEC3C (A3C), and APOBEC3F (A3F) from Vif-mediated degradation and drastically inhibit Vif function through blocking the interaction between Vif and ElonginC. Vif-ElonginC interaction inhibitor 1 enhances A3G incorporation into HIV-1 virions to reduce viral infectivity[1].
Related reactions
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Compound notes
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