| GHS classification | This chemical does not meet GHS hazard criteria for 3.2% (11 of 348) of reports.WarningH315 (18.1%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (19.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H400 (78.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (28.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]H411 (50%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 348 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 11 of 348 reports by companies.There are 10 notifications provided by 337 of 348 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
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| Regulatory information | Chemical: Zinc hydroxide (Zn(OH)2)Zinc hydroxide (Zn(OH)2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Zinc hydroxide (Zn(OH)2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/10329Zinc hydroxide: Does not have an individual approval but may be used under an appropriate group standard |
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| Hazards summary | An irritant[MSDSonline] See Zinc. |
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| Hazard Classes and Categories | Skin Irrit. 2 (18.1%)Eye Irrit. 2 (19.3%)Aquatic Acute 1 (78.4%)Aquatic Chronic 1 (28.7%)Aquatic Chronic 2 (50%) |
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| Exposure control and personal protection | 0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)] |
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| Minimum Risk Level | Intermediate Oral: 0.3 mg/kg/day (L134)
Chronic Oral: 0.3 mg/kg/day (L134) |
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| Protective Action Criteria (PAC) | 6.1 [mg/m3]67 [mg/m3]400 [mg/m3] |
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| Treatment | Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49) |
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| Health effects | Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49) |
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| Exposure routes | Inhalation (L49)oral (L49)dermal (L49) |
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| Toxicity summary | The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Hydroxide...Safe for use in cosmetics, with qualificationsAnaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49) |
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| Signs and Symptoms | Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49) |
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| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
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