Zinc Hydroxide

HCID 9812759CAS 20427-58-1

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Basic information

Standard SMILES: [OH-].[OH-].[Zn+2]
InChIKey: UGZADUVQMDAIAO-UHFFFAOYSA-L
Molecular formula: H2O2Zn
Average molar mass: 99.4 g/mol
Monoisotopic mass: 97.934621

Names & identifiers

Preferred name: Zinc Hydroxide
IUPAC: zinc dihydroxide

Names & synonyms

ZINC HYDROXIDEZinc dihydroxideOXK3V8KJ7LDTXSID7042516RefChem:904951zinc(2+) ion dihydroxideDTXCID5022516243-814-320427-58-1Zinc hydroxide (Zn(OH)2)ZINCHYDROXIDEMFCD00049620

Show more names

O2ZnZinc hydroxide [VANDF]SCHEMBL19509AKOS015833777NS00084213F510145Q204820

Database identifiers

CAS: 20427-58-1
PubChem CID: 9812759
UNII: OXK3V8KJ7L
EC Number: 243-814-3
Nikkaji: J134.217G

Properties

Computed structural properties

Topological polar surface area: 2 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 3
Formal charge: 0
Complexity: 0

Experimental & physicochemical properties

Physical Description · 2 items

Liquid; Wet Solid

Colorless solid; [Hawley] White odorless powder; [MSDSonline]

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 3.2% (11 of 348) of reports.

Warning

H315 (18.1%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (19.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H400 (78.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (28.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]；H411 (50%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 348 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 11 of 348 reports by companies.；There are 10 notifications provided by 337 of 348 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 4 items

Chemical: Zinc hydroxide (Zn(OH)2)

Zinc hydroxide (Zn(OH)2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Zinc hydroxide (Zn(OH)2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 15-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/10329

Zinc hydroxide: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryAn irritant; [MSDSonline] See Zinc.

Hazard Classes and CategoriesSkin Irrit. 2 (18.1%)；Eye Irrit. 2 (19.3%)；Aquatic Acute 1 (78.4%)；Aquatic Chronic 1 (28.7%)；Aquatic Chronic 2 (50%)

Safety & protection

Exposure Control and Personal Protection0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)]

Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)

Protective Action Criteria (PAC) · 3 items

6.1 [mg/m3]

67 [mg/m3]

400 [mg/m3]

Toxicology

TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)

Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

Exposure RoutesInhalation (L49) ; oral (L49) ; dermal (L49)

Toxicity Summary · 3 items

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Hydroxide...

Safe for use in cosmetics, with qualifications

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Signs and Symptoms · 1 item

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Regulatory information

Regulatory Information · 4 items

Chemical: Zinc hydroxide (Zn(OH)2)

Status: Active Update: 15-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/10329

Zinc hydroxide: Does not have an individual approval but may be used under an appropriate group standard

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 1 item

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)