Gallium Maltolate
Basic information
- CAS
108560-70-9- Standard SMILES
Cc1occc(=O)c1[O-].Cc1occc(=O)c1[O-].Cc1occc(=O)c1[O-].[Ga+3]- InChIKey
ASYYOZSDALANRF-UHFFFAOYSA-K- Molecular formula
- C18H15GaO9
- Average molar mass
- 445 g/mol
- Monoisotopic mass
- 443.99718
Overview
Gallium maltolate is Titan’s novel oral agent in development for the potential treatment of chronic bacterial infections, bone disease and cancer.
Names & identifiers
- Preferred name
- Gallium Maltolate
- IUPAC
- gallium tris(2-methyl-4-oxopyran-3-olate)
- English name
- GalliuM Maltolate
- Molecular formula
- C18H15GaO9
- Molecular weight
- 445.03
Names & synonyms
gallium maltolate108560-70-9tris(maltolato)gallium(III)17LEI49C2Gtris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium(III)4H-pyran-4-one, 3-hydroxy-2-methyl-, gallium salt (3:1)RefChem:142192DTXCID201527756DTXSID001045825gallium tris(2-methyl-4-oxo-4H-pyran-3-olate)gallium;2-methyl-4-oxopyran-3-olateC18H15GaO9
Show more names
GallixaGallium maltolate (Gallixa)GALLIUM MALTOLATE(108560-70-9)Gallium maltolate, 10 mM in DMSOTris[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]galliuMTris[3-(hydroxy-kappaO)-2-Methyl-4H-pyran-4-onato-kappaO4]galliuM
gallium;2-methyl-4-oxidanylidene-pyran-3-olate3-bis[(2-methyl-4-oxopyran-3-yl)oxy]gallanyloxy-2-methylpyran-4-oneGallium maltolate [WHO-DD]SCHEMBL29366290MFCD27976780DB05420DA-53477GALLIUM, TRIS(3-(HYDROXY-.KAPPA.O)-2-METHYL-4H-PYRAN-4-ONATO-.KAPPA.O4)-, (OC-6-21)-
Database identifiers
- CAS
108560-70-9
Properties
Computed structural properties
- Topological polar surface area
- 148 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 0
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 200
Physicochemical properties
- form
- Solid
- color
- Off-white to light yellow
- Cosmetics Ingredients Functions
- SKIN CONDITIONING
- InChI
- InChI=1S/3C6H4O5.Ga/c3*7-3-1-2-11-5(4(3)8)6(9)10;/h3*1-2,8H,(H,9,10);/q;;;+3/p-3
- InChIKey
- LRPKBZSTANNRLK-UHFFFAOYSA-K
- SMILES
- [Ga+3].O1C(C([O-])=O)=C(O)C(=O)C=C1.O1C(C([O-])=O)=C(O)C(=O)C=C1.O1C(C([O-])=O)=C(O)C(=O)C=C1
- FDA UNII
- 17 LEI49C2G · 17LEI49C2G
- NCI Drug Dictionary
- gallium maltolate
Chemistry & industry
Pharmacology
Mechanism of Action
Gallium maltolate is a novel orally active formulation of gallium, a semi-metallic element that is a potent inhibitor of ribonucleotide reductase, an enzyme that promotes tumor growth.Gallium is also known to concentrate in malignant tumors and sites of infection, and appears to favorably impact calcium deposition, making bones more resistant to degradation caused by cancer metastasis. Titan's novel product, gallium maltolate, may significantly expand the therapeutic potential of gallium by providing the advantages of enhanced bioavailablity, a potentially improved therapeutic profile and ease of administration.
Applications
DescriptionGallium maltolate (GaM) is a new orally administered compound that has the potential to fundamentally improve the lives of many of these patients by providing effective treatment without serious side effects. GaM is being developed as an orally active formulation of gallium, a drug already approved by the FDA in intravenous form (gallium nitrate for injection). Clinical and preclinical studies have repeatedly shown gallium to have efficacy against cancer, inflammatory disorders, infectious disease, and bone loss.
Suppliers
Loading…
Open inquiries
Loading…
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…