Boc-Lys(Ac)-AMC

HCID 9846360

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Basic information

CAS: 233691-67-3
Standard SMILES: CC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc2c(C)cc(=O)oc2c1
InChIKey: SUTRDULVNIPNLW-SFHVURJKSA-N
Molecular formula: C23H31N3O6
Average molar mass: 445.5 g/mol
Monoisotopic mass: 445.22128572

Names & identifiers

Preferred name: Boc-Lys(Ac)-AMC
IUPAC: tert-butyl N-[(2S)-6-acetamido-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]carbamate
English name: BOC-LYS(AC)-AMC
Molecular formula: C23H31N3O6
Molecular weight: 445.51

Names & synonyms

Boc-Lys(Ac)-AMC233691-67-3DTXSID90431743RefChem:330048DTXCID80382573(S)-tert-Butyl (6-acetamido-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)carbamateBoc-L-Lys(Ac)-AMCMFCD02683946fluorescent substrateBoc-Lys(Ac)-Amc-OHHDAC Substrate (Fluorometric)tert-butyl N-[(2S)-6-acetamido-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]carbamate

Show more names

MALBOC-LYSINE(AC)-AMC(Tert-Butoxy)Carbonyl Lys(Ac)-AMCHISTONE DEACETYLASE SUBSTRATE, FLUOROGENICHISTONE DEACETYLASE SUBSTRATE (FLUOROMETRIC)Nα-Boc-Nε-acetyl-L-lysine 7-amido-4-methylcoumarin

Carbamic acid, N-[(1S)-5-(acetylamino)-1-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl]pentyl]-, 1,1-dimethylethyl esterF10782tert-butyl N-[(1S)-5-acetamido-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]pentyl]carbamateBDBM24625Boc-L(Ac)-AMCNalpha-Boc-Nepsilon-acetyl-L-lysine 7-amido-4-methylcoumarinBoc-Lys(Ac)-7-Amino-4-MethylcoumarinBoc-Ac-Lys-AMC

Database identifiers

CAS: 233691-67-3
PubChem CID: 9846360
DTXSID: DTXSID90431743
ChEMBL: CHEMBL184757
Nikkaji: J1.130.433H

Properties

Computed structural properties

XLogP: 2.2
Topological polar surface area: 123 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 6
Rotatable bonds: 10
Heavy atoms: 32
Formal charge: 0
Complexity: 743

Physicochemical properties

Boiling point: 732.6 · 732.6±60.0 °C(Predicted)
Density: 1.209 · 1.209±0.06 g/cm3(Predicted)
storage temp.: -20 °C · Sealed in dry,Store in freezer, under -20°C
solubility: 30 mg/ml; · DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml
form: White crystalline solid
pka: 11.23 · 11.23±0.46(Predicted)
color: White to off-white
InChIKey: SUTRDULVNIPNLW-SFHVURJKSA-N
UNSPSC Code: 12352200 · 12352200
WGK Germany: 3 · WGK 3
HS Code: 2932209090 · 2932209090
Storage Class: 11 · 11 - Combustible Solids

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

Safety data

wgk: WGK 3
hs_code: 2932209090
Storage Class: 11 - Combustible Solids

Chemistry & industry

Applications · 2 items

DescriptionBoc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs). Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

UsesBoc-Lys(Ac)-AMC is a cell-permeable fluorometric HDAC substrate (Ex/Em = 355 nm/460 nm)[1][2].

Suppliers67 total

Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

江苏生康迈翔科技有限公司18217475093 · [email protected]

毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]

上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]

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