L 768673
Basic information
- CAS
177954-68-6- Standard SMILES
O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O- InChIKey
VVCYJFVTVHMTBV-HSZRJFAPSA-N- Molecular formula
- C27H18F9N3O2
- Average molar mass
- 587.4 g/mol
- Monoisotopic mass
- 587.12553028
Overview
blocks slowly activating cardiac delayed rectifier potassium channel; structure in first source
Names & identifiers
- Preferred name
- L 768673
- IUPAC
- 2-[2,4-bis(trifluoromethyl)phenyl]-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]acetamide
Names & synonyms
L-768673177954-68-6l-768,673L 768673RefChem:151726L 768,6732-[2,4-Bis(trifluoromethyl)phenyl]-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]acetamideCHEMBL16900Benzeneacetamide, N-[(3R)-2,3-dihydro-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-1,4-benzodiazepin-3-yl]-2,4-bis(trifluoromethyl)-SCHEMBL7207125VVCYJFVTVHMTBV-HSZRJFAPSA-NDTXSID501380969
Show more names
GLXC-07185BDBM500612092-(2,4-Bis-trifluoromethyl-phenyl)-N-[(R)-2-oxo-5-phenyl-1-(2,2,2-trifluoro-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-acetamide
Database identifiers
- CAS
177954-68-6- PubChem CID
- 9851380
- DTXSID
DTXSID501380969- ChEMBL
CHEMBL16900- Nikkaji
- J901.442J
Properties
Computed structural properties
- XLogP
- 6.5
- Topological polar surface area
- 61.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 5
- Heavy atoms
- 41
- Formal charge
- 0
- Complexity
- 973
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationA class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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