Basic information
- CAS
193012-35-0- Standard SMILES
CCCCCS(=O)(=O)NC(=O)c1ccc2nc(C)n(Cc3ccc(Cl)cc3Cl)c2c1- InChIKey
UYGZODVVDUIDDQ-UHFFFAOYSA-N- Molecular formula
- C21H23Cl2N3O3S
- Average molar mass
- 468.4 g/mol
- Monoisotopic mass
- 467.08371796
Overview
FK614 has been used in trials studying the treatment of Diabetes Mellitus.
Names & identifiers
- Preferred name
- FK-614
- IUPAC
- 3-[(2,4-dichlorophenyl)methyl]-2-methyl-N-pentylsulfonylbenzimidazole-5-carboxamide
- English name
- FK-614
- Molecular formula
- C21H23Cl2N3O3S
- Molecular weight
- 468.4
Names & synonyms
FK-614193012-35-0FK 614UNII-V5Q32BZX79V5Q32BZX79ATx08-0013-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3 H-benzimidazole-5-carboxamide1-[(2,4-dichlorophenyl)methyl]-2-methyl-N-(pentane-1-sulfonyl)-1H-1,3-benzodiazole-6-carboxamide3-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide1-(2,4-dichlorobenzyl)-2-methyl-6-(1-pentanesulfonylcarbamoyl)benzimidazole1-((2,4-dichlorophenyl)methyl)-2-methyl-N-(pentane-1-sulfonyl)-1H-1,3-benzodiazole-6-carboxamideFK614 cpd
Show more names
ATx-08001ATx-08-0011H-Benzimidazole-6-carboxamide, 1-[(2,4-dichlorophenyl)methyl]-2-methyl-N-(pentylsulfonyl)-
RefChem:140532FK6141-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-1H-benzo[d]imidazole-6-carboxamide3-[(2,4-dichlorophenyl)methyl]-2-methyl-N-pentylsulfonylbenzimidazole-5-carboxamideSCHEMBL682052CHEMBL3545278SCHEMBL29368164SCHEMBL29691565
Database identifiers
- CAS
193012-35-0- PubChem CID
- 9869229
- DTXSID
DTXSID60940978- ChEMBL
CHEMBL3545278- UNII
- V5Q32BZX79
- Nikkaji
- J2.256.331I
Properties
Computed structural properties
- XLogP
- 5.3
- Topological polar surface area
- 89.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 8
- Heavy atoms
- 30
- Formal charge
- 0
- Complexity
- 687
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Density
- 1.37 · 1.37±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 100 mg/mL · DMSO : 100 mg/mL (213.49 mM; Need ultrasonic)
- form
- Solid
- pka
- 2.53 · 2.53±0.40(Predicted)
- color
- White to off-white
- FDA UNII
- 5 Q32BZX79 · V5Q32BZX79
Chemistry & industry
Applications
UsesFK 614 is a novel non-thiazolidinedione (TZD) peroxisome proliferator-activated receptor (PPAR) γ agonist, that ameliorates insulin resistance in Zucker fatty rats.
Suppliers18 total
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
Suzhou ARTK Medchem Co., Ltd.+86-18168183658 · [email protected]
Aladdin Scientific[email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
United Life Science020-82099279 18988941402 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
南京药石科技股份有限公司4000255188 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
开封明仁药业有限公司0371-65741762 · [email protected]
苏州美石生物科技有限公司1173954148q · [email protected]
武汉多普乐生物医药有限公司+86-02787215551 19945035818 · [email protected]
上海源叶生物科技有限公司13636370518 · [email protected]
武汉沃格达生物科技有限公司15071299552 · [email protected]
上海超岚化工科技中心QQ：65489617 13301690235 · [email protected]
深圳市祥根生物医药有限公司0755-28967200 13631290199 · [email protected]
上海立崎生物医学研究中心18014399201 · [email protected]
济南药研药物化学有限公司[email protected]
南京美韬医药科技有限公司[email protected] · [email protected]
Related reactions
2 records
Compound notes
Loading…