Basic information
- CAS
146929-33-1- Standard SMILES
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC.Cl- InChIKey
SKDIDWRQDBIQBS-MCJVGQIASA-N- Molecular formula
- C23H28ClN5O4
- Average molar mass
- 474 g/mol
- Monoisotopic mass
- 473.1829821
Overview
Cyclazosin hydrochloride is a hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride. It has a role as an alpha1B-adrenoceptor antagonist. It contains a cyclazosin.
Names & identifiers
- Preferred name
- Cyclazosin hydrochloride
- IUPAC
- [(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone;hydrochloride
- English name
- CYCLAZOSIN HYDROCHLORIDE
- Molecular formula
- C23H27N5O4
- Molecular weight
- 473.95
Names & synonyms
Cyclazosin hydrochlorideCyclazosin HCl(+)-Cyclazosin hydrochlorideUNII-RLN802138LRLN802138LDTXSID1040453CHEBI:63935((4aR,8aS)-4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl)(2-furyl)methanone hydrochloride (1:1)((4aR,8aS)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)-(furan-2-yl)methanone hydrochloride((4aR,8aS)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl)(2-furyl)methanone hydrochloride(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-L-yl)furan-2-ylmethanone hydrochlorideMethanone, ((4aR,8aS)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl)-2-furanyl-, hydrochloride (1:1), rel-
Show more names
CYCLAZOSIN HYDROCHLORICyclazosin monohydrochlorideCyclazosin Hydrochloride CDPCyclazosin hydrochloride SolutionCYCLAZOSIN HYDROCHLORIDE USP/EP/BPCyclazosin hydrochloride Solution, 100ppm
Properties
Computed structural properties
- Topological polar surface area
- 107 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 4
- Heavy atoms
- 33
- Formal charge
- 0
- Complexity
- 668
Physicochemical properties
- solubility
- 2 O: · H2O: 1.8 mg/mL
- form
- solid
- color
- white
- Water Solubility
- 2 O: · H2O: 1.8mg/mLmethanol: 14mg/mLDMSO: 2.5mg/mL
- InChIKey
- SKDIDWRQDBIQBS-NAHYZYKJNA-N
- SMILES
- [C@@]12([H])CCCC[C@]1([H])N(CCN2C1=NC(=C2C=C(OC)C(OC)=CC2=N1)N)C(=O)C1OC=CC=1.Cl |&1:0,6,r|
- CAS DataBase Reference
- 146929 · 146929-33-1
- FDA UNII
- 802138 L · RLN802138L
- UNSPSC Code
- 12352202 · 12352202
- NACRES
- 77 · NA.77
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- WGK Germany
- 3 · 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesCyclazosin hydrochloride is prazosin-related α1-adrenoceptor antagonist at α1-, α2-adrenoceptors, dopamine D2 and 5-HT1A receptors.
Suppliers56 total
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
江苏瑞点药业有限公司15896106238 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
郑州汇聚化工有限公司0371-53399770 18037166334 · [email protected]
Shaanxi LonierHerb Bio Technology Co Ltd+86-86-+86-86-029-87551862 15002946897 · [email protected]
湖北科麦迪化工有限公司18372743325 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
Shenzhen Monkono Technology Co.,Ltd+86-17063441314 · [email protected]
Shandong Hanjiang Chemical Co., Ltd+86-0533-2066820 +8618369939125 · [email protected]
上海波以尔化工有限公司[email protected]
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.—
深圳市思美泉生物科技有限公司17683743113;18038040196 · [email protected]
Related reactions
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Compound notes
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