Periodate-oxidized adenosine
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Basic information
- CAS
34240-05-6- Standard SMILES
Nc1ncnc2c1ncn2C(C=O)OC(C=O)CO- InChIKey
ILMNSCQOSGKTNZ-UHFFFAOYSA-N- Molecular formula
- C10H11N5O4
- Average molar mass
- 265.23 g/mol
- Monoisotopic mass
- 265.08110385
Overview
RN given refers to cpd without isomeric designation
Names & identifiers
- Preferred name
- Periodate-oxidized adenosine
- IUPAC
- 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal
- English name
- ADENOSINE, PERIODATE OXIDIZED
- Molecular formula
- C10H11N5O4
- Molecular weight
- 265.23
Names & synonyms
Adenosine dialdehyde34240-05-6Hydracrylaldehyde, 2-((6-amino-9H-purin-9-yl)formylmethoxy)-alpha-(Hydroxymethyl)-alpha'-(6-aminopurin-9-yl)diglycolaldehyde6-Amino-alpha-(1-formyl-2-hydroxyethoxy)-9H-purine-9-acetaldehyde9H-Purine-9-acetaldehyde, 6-amino-alpha-(1-formyl-2-hydroxyethoxy)-NSC 26675439798-19-1PI-adenosine9H-Purine-9-acetaldehyde, 6-amino-alpha-(1-formyl)-2-(hydroxyethoxy)-, (R-(R*,R*))-RefChem:171776ADOX
Show more names
AdenosineDialdehyde(ADOX)ADENOSINE-2',3'-DIALDEHYDEperiodate-oxidizedadenosineADENOSINE, PERIODATE OXIDIZEDAdenosine, periodate oxidized >=93%4'-Bromo-N,N-diphenyl-4-biphenylamineAdenosine Dialdehyde (ADOX), 10 mM in DMSO2-(1-(6-aMino-9H-purin-9-yl)-2-oxoethoxy)-3-hydroxypropanalGuanosine, 2′-deoxy-3′-O-[(1-methylethylidene)amino]- (ACI)
Adenox2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal2-[1-(6-aminopurin-9-yl)-2-oxo-ethoxy]-3-hydroxy-propanalNSC49928AdenosinedialdehydeDTXSID60955784ADOX (Adenosine Dialdehyde)CHEMBL281476
Database identifiers
- CAS
34240-05-6、39798-19-1- PubChem CID
- 99920
- DTXSID
DTXSID60955784- ChEMBL
CHEMBL281476- Nikkaji
- J429.050J
Properties
Computed structural propertiesFilling in
- XLogP
- -1.6
- Topological polar surface area
- 133 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 6
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 331
Physicochemical properties
- Boiling point
- 532.9 · 532.9±60.0 °C(Predicted)
- Density
- 1.69 · 1.69±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 13.72 · 13.72±0.10(Predicted)
- color
- White to off-white
- biological source
- synthetic (organic)
- InChI
- 1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
- InChIKey
- ILMNSCQOSGKTNZ-UHFFFAOYSA-N
- SMILES
- Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
- EWG's Food Scores
- 1 · 1
- UNSPSC Code
- 41106305 · 41106305
- NACRES
- 51 · NA.51
- Symbol(GHS)
- 8 · GHS08
- Signal word
- Danger
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type N95 (US)
- wgk
- 1
- risk_code
- 36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- hazard_code
- Xi
- safety_code
- 26-36
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H370
- Precautionary statements
- P260-P264-P270-P307+P311-P321-P405-P501
Chemistry & industry
Applications
UsesAdenosine, periodate oxidized has been used: as a methylarginine transferase inhibitor in the human embryonic kidney (HEK)-293 T cells as a methylase inhibitor in H4 neurogliomaas a broad inhibitor of S-adenosylmethionine (AdoMet)-dependent methyltransferases in mouse embryo fibroblast NIH3T3 cells
Uses2-(1-(6-aMino-9H-purin-9-yl)-2-oxoethoxy)-3-hydroxypropanal is an inhibitor of S-adenosylhomocysteine hydrolase (AdoHcy hydrolase ) and it may be used in studies on the role of AdoHcy hydrolase in adenosine induce apoptosis and related S-adenosylhomocysteine-regulated processes. Adox is a methylation inhibitor that inhibits histone methytransferases (HMTase) and arginine methylation.
Related reactions
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Compound notes
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