{4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester → [4-((5-Chloro-3-methyl-pyridin-2-ylmethyl)-{3-[1-(4-fluoro-phenyl)-1-methyl-ethyl]-pyridin-2-ylmethyl}-amino]-butyl]-methyl-carbamic acid tert-butyl ester

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH3:8])[CH2:9][CH2:10][CH2:11][CH2:12][NH:13][CH2:14][c:15]1[n:16][cH:17][c:18]([Cl:22])[cH:19][c:20]1[CH3:21])=[O:23].[F:24][c:25]1[cH:26][cH:27][c:28]([C:31]([CH3:32])([CH3:33])[c:34]2[c:35]([CH:40]=[O:41])[n:36][cH:37][cH:38][cH:39]2)[cH:29][cH:30]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH3:8])[CH2:9][CH2:10][CH2:11][CH2:12][N:13]([CH2:14][c:15]1[n:16][cH:17][c:18]([Cl:22])[cH:19][c:20]1[CH3:21])[CH2:40][c:35]1[c:34]([C:31]([c:28]2[cH:27][cH:26][c:25]([F:24])[cH:30][cH:29]2)([CH3:32])[CH3:33])[cH:39][cH:38][cH:37][n:36]1)=[O:23]