Potassium Hydroxide → 1-Isopropylpiperazine
Reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>CO>[CH:10]([N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)([CH3:12])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 7.26 g of 1-acetyl-4-isopropylpiperazine were added 100 ml of methanol and 10 g of potassium hydroxide and the mixture was heated under reflux for 17 hours. After the solvent was distilled off, water and chloroform were added. The mixture was extracted with chloroform and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to afford 5.78 g of the title compound as an oily substance.
Workup
- temperaturethe mixture was heated
- temperatureunder reflux for 17 hours
- distillationAfter the solvent was distilled off
- additionwater and chloroform were added
- extractionThe mixture was extracted with chloroform
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off under reduced pressure
Sources & evidence
- ORD record
- ord-e6d544aed0e04eabb6fdd9f3a082a8f0
- Source dataset
- uspto-grants-2000_04
- Patent number
- US06046201
Reaction notes
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