Fludarabine Phosphate → Fludarabine phosphate magnesium salt

HRID 1003722

Reaction equation

HRID 1003722 reaction equation
[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][O:16][P:17]([OH:20])([OH:19])=[O:18])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[O-2].[Mg+2:26]>O>[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[Mg+2:26].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[Mg+2:26].[Mg+2:26]

Participants

4

Reactant 2

HCID 30751Fludarabine PhosphateHCID 6850729Magnesium monoxide

Product 1

HCID 86755286Fludarabine phosphate magnesium saltYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10.0 g of fludarabine phosphate at a purity of 97.5% is suspended in 100 ml of water within about 5 minutes, and magnesium oxide is added to this solution. The mixture is stirred for one more hour at room temperature and then filtered. The clear solution is poured into 200 ml of acetone, stirred for 1 more hour, and the crystallizate is separated by filtration. 10.0 g (95% of theory) of the fludarabine-phosphate magnesium salt is obtained.

Workup

  1. filtrationfiltered
  2. additionThe clear solution is poured into 200 ml of acetone
  3. stirringstirred for 1 more hour
  4. customthe crystallizate is separated by filtration

Sources & evidence

ORD record
ord-51090bcb15194d508c3c7e0872bdadfc
Source dataset
uspto-grants-2000_04
Patent number
US06046322

Linked notes

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