3-[(Thiophen-2-ylmethyl)-amino]-phthalic acid dimethyl ester → 3-[(Thiophen-2-ylmethyl)-amino]-phthalic acid

HRID 10038

Reaction equation

HRID 10038 reaction equation
C[O:2][C:3](=[O:21])[C:4]1[C:5](=[C:10]([NH:14][CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)[CH:11]=[CH:12][CH:13]=1)[C:6]([O:8]C)=[O:7].COCCNC1C=CC=C(C(O)=O)C=1C(O)=O>>[S:17]1[CH:18]=[CH:19][CH:20]=[C:16]1[CH2:15][NH:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:4]([C:3]([OH:21])=[O:2])[C:5]=1[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 210401383-[(Thiophen-2-ylmethyl)-amino]-phthalic acid dimethyl esterHCID 219885193-(2-Methoxy-ethylamino)-phthalic acid

Product 1

HCID 219885963-[(Thiophen-2-ylmethyl)-amino]-phthalic acid

Procedure

3-[(Thiophen-2-ylmethyl)-amino]-phthalic acid dimethyl ester (0.88 g, 2.88 mmol) was treated in the same manner as described above for the synthesis 3-(2-methoxy-ethylamino)-phthalic acid. The product of the reaction, which contained a mixture of diacid and monomethyl esters, was used without further purification.

Workup

  1. customThe product of the reaction, which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-46080862d7464522ad108ad03c61ee7c
Source dataset
uspto-grants-2006_08
Patent number
US07091353B2

Linked notes

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