Citric Acid → HCID 14150070, compound

HRID 1003946

Reaction equation

HRID 1003946 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([I:9])[CH:5]=[C:6]([OH:8])[CH:7]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11].C(O)(=O)[CH2:18][C:19](CC(O)=O)(C(O)=O)[OH:20]>N1C=CC=CC=1>[C:10]([O:1][C:2]1[CH:3]=[C:4]([I:9])[CH:5]=[C:6]([O:8][C:19](=[O:20])[CH3:18])[CH:7]=1)(=[O:12])[CH3:11]

Participants

5

Reactant 3

HCID 311Citric AcidHCID 7918Acetic AnhydrideHCID 6167555-Iodobenzene-1,3-diol

Product 1

HCID 14150070HCID 14150070, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

NMR (CDCl3) δ: 5.22 (2H, s), 6.31 (1H, t, J=2.5), 6.79 (2H, d, J=2.5) (3) 3,5-Dihydroxyiodobenzene (1.02 g) is dissolved in pyridine (2.8 ml), and thereto is added acetic anhydride (1.53 g) at room temperature. The mixture is stirred for one hour, and the reaction mixture is poured into 10% aqueous citric acid solution, and extracted with ethyl acetate. The organic layer is washed with water, dried, and concentrated under reduced pressure to give 3,5-diacetoxyiodobenzene (1.37 g).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer is washed with water
  3. customdried
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-84aaebe697db4d70b600a4a24e88e8d0
Source dataset
uspto-grants-2000_04
Patent number
US06048842

Linked notes

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