(2-Methyl-1,3-thiazol-4-yl)acetic acid → HCID 53822826, compound
Reaction equation
[OH:1][C@H:2]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:3][N:4]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[CH3:29][C:30]1[S:31][CH:32]=[C:33]([CH2:35][C:36](O)=[O:37])[N:34]=1>>[OH:1][C@H:2]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:3][N:4]([CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([NH:20][C:36](=[O:37])[CH2:35][C:33]2[N:34]=[C:30]([CH3:29])[S:31][CH:32]=2)=[CH:18][CH:19]=1)[C:5](=[O:11])[O:6][C:7]([CH3:9])([CH3:10])[CH3:8]Participants
3
Procedure
621 mg of t-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-(4-aminophenyl)ethyl]carbamate and 403 mg of 2-(2-methylthiazol-4-yl) acetic acid were subjected to an amidation reaction to obtain 765 mg of t-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-[4-[[2-(2-methylthiazol-4-yl)acetyl]-amino]phenyl]ethyl]carbamate.
Sources & evidence
- ORD record
- ord-1ced46c848974c2b9f8f13acbdb5b7fc
- Source dataset
- uspto-grants-2000_04