Methanol → Methyl (2-chlorophenyl)acetate
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-chlorophenylacetic acid (10.0 g) in methanol (100 ml) containing 1 drop of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was evaporated to half volume and partitioned between ethyl acetate (100 ml) and water (100 ml). The organic phase was dried over magnesium sulphate and evaporated to give the title compound (10.0 g) as a colourless oil.
Workup
- temperaturewas heated
- temperatureat reflux for 2 hours
- customThe reaction mixture was evaporated to half volume
- custompartitioned between ethyl acetate (100 ml) and water (100 ml)
- dry with materialThe organic phase was dried over magnesium sulphate
- customevaporated
Sources & evidence
- ORD record
- ord-9fca659e73f847a3a5eb5a0804ca6a53
- Source dataset
- uspto-grants-2000_04
- Patent number
- US06048893
Reaction notes
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