3-(3-Benzyloxy-4-bromo-phenylamino)-but-2-enoic acid ethyl ester → 7-Benzyloxy-6-bromo-2-methyl-quinolin-4-ol
Reaction equation
C(O[C:4](=[O:24])[CH:5]=[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[C:11]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:10]=1)[CH3:7])C>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH2:17]([O:16][C:11]1[CH:10]=[C:9]2[C:14]([C:4]([OH:24])=[CH:5][C:6]([CH3:7])=[N:8]2)=[CH:13][C:12]=1[Br:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1Participants
3
Conditions
- Temperature
- 250 °C
Procedure
Dowtherm®A (320 mL) was heated to 250° C. then a solution of 3-(3-benzyloxy-4-bromo-phenylamino)-but-2-enoic acid ethyl ester (55.5 g, 99.5 mmol) in Dowtherm®A (120 mL) was slowly added. The reaction mixture was heated 16 min at 250° C. and ethanol was collected by distillation. The mixture was cooled down, diluted with hexanes (1.5 L) and filtered. The solid was washed with ether and dried under vacuum. 73.0 g of the title compound were obtained. Brown solid, ISP-MS: m/e=345.2 ([M+H]+).