Nitric Acid → HCID 86588302, compound

HRID 1007076

Reaction equation

HRID 1007076 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:3]=1.[N+:18]([O-:21])([OH:20])=[O:19]>CO.C(#N)C>[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:3]=1.[N+:18]([O-:21])([O-:20])=[O:19]

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 5329Sulfamethoxazole

Product 1

HCID 86588302HCID 86588302, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

The compound is prepared by starting from a Sulfamethoxazole solution (2 g, 7.9 mmoli) in methanol (100 ml), addition of a 65% nitric acid solution (0.500 ml) in acetonitrile (5 ml), following the procedure reported in Example 5. Sulfamethoxazole nitrate as amorphous solid is obtained. Yield 60%.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-7e868392ac6d4e0dbe7cd7f6fb4e6bd2
Source dataset
uspto-grants-2004_09
Patent number
US06794372B2

Linked notes

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