HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178427847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-(4-oxocyclohexyl)-1,3-benzoxazol-2(3H)-one | HCID 9813382 | — |
| Reactant | 3-(4-Fluoro-2-methylphenyl)propan-1-amine | HCID 22669137 | — |
| Product | HCID 178427847 | HCID 178427847 | 56% |
Reaction Steps
Coupling of ketone 5 and 3-(4-fluoro-2-methylphenyl)-1-propylamine, using the method given in Example 1, gave 6-(trans-4-[3-(4-fluoro-2-methylphenyl)propylamino]cyclohexyl}-3H-benzoxazol-2-one (630 mg, 56%) as the HCl salt: 1H NMR (500 MHz, DMSO-d6): δ 11.50 (s, 1H), 8.88 (s, 2H), 7.22-7.13 (m, 2H), 7.05-6.91 (m, 4H), 3.09-2.87 (m, 3H), 2.67-2.62 (m, 3H), 2.30 (s, 3H), 2.17-2.13 (m, 2H), 1.92-1.79 (m, 4H), 1.58-1.41 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794402B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-ed46d4f280d44637af94289c2c108475 |
| Source note | uspto-grants-2004_09 |