4-Benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine → 2,3,4,5-Tetrahydro-1,4-benzoxazepine
Reaction equation
C([N:8]1[CH2:14][C:13]2[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=2[O:11][CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[O:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[CH2:14][NH:8][CH2:9][CH2:10]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
10.2 g of 4-benzyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine were dissolved in 100 mL of ethanol and hydrogenated for 5 hours at room temperature using 1.2 g of palladium (10% on carbon) as catalyst. Filtration followed by removal of the solvent in vacuo gave 6.1 g of 2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine as an oil. EI-MS: 149 (M+).
Workup
- filtrationFiltration
- customfollowed by removal of the solvent in vacuo
Sources & evidence
- ORD record
- ord-815c93cf37a04f1885adf2c5159f7073
- Source dataset
- uspto-grants-2004_09
- Patent number
- US06797710B2
Reaction notes
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