2-Ethylazepane → HCID 59341131, compound

HRID 1008740

Reaction equation

HRID 1008740 reaction equation
Cl[C:2]1[C:7]([F:8])=[C:6]([Cl:9])[N:5]=[CH:4][N:3]=1.[CH2:10]([CH:12]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13]1)[CH3:11]>>[Cl:9][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH:12]2[CH2:10][CH3:11])[C:7]=1[F:8]

Participants

3

Reactant 2

HCID 43359322-EthylazepaneHCID 112866754,6-Dichloro-5-fluoropyrimidine

Product 1

HCID 59341131HCID 59341131, compoundYield 97.2%

Procedure

0.4 g of 4,6-dichloro-5-fluoropyrimidine and 0.61 g of 2-ethylhexahydro-1H-azepine were mixed and left for 1 hour at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.6 g of 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine.

Sources & evidence

ORD record
ord-0c7cc54ad20e4b25b41b1ae073ca6079
Source dataset
uspto-grants-2011_07
Patent number
US07973028B2

Linked notes

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