Lactic Acid → Isonicotinic Acid Amide Lactic Acid
Reaction equation
C1SC(NC(N)=N)=NC=1CSCCC(NS(N)(=O)=O)=N.[C:21]([NH2:29])(=[O:28])[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[C:30]([OH:35])(=[O:34])[CH:31]([CH3:33])[OH:32]>O>[C:21]([NH2:29])(=[O:28])[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[C:30]([OH:35])(=[O:34])[CH:31]([CH3:33])[OH:32]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.