Lactic Acid → Isonicotinic Acid Amide Lactic Acid

HRID 10119

Reaction equation

HRID 10119 reaction equation
C1SC(NC(N)=N)=NC=1CSCCC(NS(N)(=O)=O)=N.[C:21]([NH2:29])(=[O:28])[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[C:30]([OH:35])(=[O:34])[CH:31]([CH3:33])[OH:32]>O>[C:21]([NH2:29])(=[O:28])[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[C:30]([OH:35])(=[O:34])[CH:31]([CH3:33])[OH:32]

Participants

5

Reactant 3

HCID 612Lactic AcidHCID 15074IsonicotinamideHCID 178418935HCID 178418935, compound2×

Product 1

HCID 86591738Isonicotinic Acid Amide Lactic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.

Workup

  1. dissolutionto dissolve them
  2. additionwas added
  3. customa kinematic viscosity at room temperature of 0.95 centistokes was obtained

Sources & evidence

ORD record
ord-6961669486c8494bb2c3a3bdd60048e7
Source dataset
uspto-grants-2006_08
Patent number
US07094414B2

Linked notes

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