2-(1-Methyl-1H-imidazol-4-yl)ethanamine bis(4-methylbenzenesulfonate) → 1-Methylhistamine

HRID 1014963

Reaction equation

HRID 1014963 reaction equation
CC1C=CC(S(O)(=O)=O)=CC=1.CC1C=CC(S(O)(=O)=O)=CC=1.[CH3:23][N:24]1[CH:28]=[C:27]([CH2:29][CH2:30][NH2:31])[N:26]=[CH:25]1>O>[CH3:23][N:24]1[CH:28]=[C:27]([CH2:29][CH2:30][NH2:31])[N:26]=[CH:25]1

Participants

3

Reactant 1

HCID 862548242-(1-Methyl-1H-imidazol-4-yl)ethanamine bis(4-methylbenzenesulfonate)

Product 1

HCID 36141-Methylhistamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

[2-(1-methyl-1H-imidazol-4-yl)ethyl]amine bis(4-methylbenzenesulfonate) (50 g) was dissolved in IMS (200 ml)/water (200 ml). This was passed through a DOWEX550A column (600 g), eluting with IMS (ca. 4 litres). Appropriate fractions were combined and concentrated in vacuo to yield the title compound, 13.4 g.

Workup

  1. washeluting with IMS (ca. 4 litres)
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f3da4045887c466dbdc32a66a7e10fda
Source dataset
uspto-grants-2011_07
Patent number
US07985740B2

Linked notes

Loading…