1-(2-Nitro-vinyl)-4-trifluoromethyl-benzene → 2-[4-(Trifluoromethyl)phenyl]ethan-1-amine

Reaction equation

[N+:1]([CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=1)([O-])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:13][C:12]([F:14])([F:15])[C:9]1[CH:8]=[CH:7][C:6]([CH2:5][CH2:4][NH2:1])=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 6882311-(2-Nitro-vinyl)-4-trifluoromethyl-benzene

HCID 21226445Aluminium lithium hydride

Product 1

HCID 19881062-[4-(Trifluoromethyl)phenyl]ethan-1-amine

Procedure

In close analogy to the procedure described above, 1-(2-Nitro-vinyl)-4-trifluoromethyl-benzene is reacted with lithium aluminium hydride to provide the title compound.

Sources & evidence

ORD record: ord-4bda679ec5934c3bbf41e72806cf7686
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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