Boronic Acid → 6-(3-Pyridyl)-1,2,3,4-tetrahydroisoquinoline

Reaction equation

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2.B(O)O>>[N:7]1[CH:8]=[CH:9][CH:4]=[C:5]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[CH2:8][NH:7][CH2:6][CH2:5]3)[CH:6]=1

Participants

Reactant 2

HCID 61668Boronic Acid

HCID 158851836-Bromo-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 584163586-(3-Pyridyl)-1,2,3,4-tetrahydroisoquinoline

Procedure

In close analogy to the procedure described above, 6-Bromo-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Sources & evidence

ORD record: ord-eb801d94d433453ba7c2d4b1cbbabd2b
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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