Boronic Acid → 1-Methyl-7-pyridin-3-yl-1,2,3,4-tetrahydro-isoquinoline

Reaction equation

Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH:9]2[CH3:12])=[CH:4][CH:3]=1.B(O)O>>[CH3:12][CH:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([C:6]3[CH:7]=[N:8][CH:9]=[CH:10][CH:5]=3)[CH:11]=2)[CH2:6][CH2:7][NH:8]1

Participants

Reactant 2

HCID 61668Boronic Acid

HCID 584164221176414-95-1

Product 1

HCID 584163871-Methyl-7-pyridin-3-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 7-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Sources & evidence

ORD record: ord-0fe3b1015eb04bba92a020d7b7dfecf2
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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