5-Bromoisoquinoline → HCID 56917206, compound

Reaction equation

Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.C[Sn](C)(C)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1.[BH4-].[Na+]>>[N:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

Participants

Reactant 3

HCID 7364875-Bromoisoquinoline

HCID 4311764Sodium borohydride

HCID 11021057Pyridine, 2-(trimethylstannyl)-

Product 1

HCID 56917206HCID 56917206, compound

Procedure

In close analogy to the procedure described above, 5-Bromo-isoquinoline is reacted with 2-trimethylstannyl-pyridine and sodium borohydride to provide the title compound.

Sources & evidence

ORD record: ord-f2ec2d3dcd774790b46d8995ad3a5547
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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