Potassium Cation → 3-Bromo-7-(2-fluoropyridin-3-yl)-5',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazin]-2'-amine

HRID 101566

Reaction equation

HRID 101566 reaction equation
[Br:7][c:8]1[cH:9][c:10]2[c:11]([n:12][cH:13]1)[O:14][c:15]1[cH:16][cH:17][c:18]([I:28])[cH:19][c:20]1[C:21]21[N:22]=[C:23]([NH2:27])[O:24][CH2:25][CH2:26]1.[C:1](=[O:2])([O-:3])[O-:4].[F:29][c:30]1[n:31][cH:32][cH:33][cH:34][c:35]1[B:36]([OH:37])[OH:38].[K+:5].[K+:6].[O:39]1[CH2:40][CH2:41][O:42][CH2:43][CH2:44]1.[OH2:45]>>[Br:7][c:8]1[cH:9][c:10]2[c:11]([n:12][cH:13]1)[O:14][c:15]1[cH:16][cH:17][c:18](-[c:35]3[c:30]([F:29])[n:31][cH:32][cH:33][cH:34]3)[cH:19][c:20]1[C:21]21[N:22]=[C:23]([NH2:27])[O:24][CH2:25][CH2:26]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 27832702-Fluoropyridine-3-boronic acidHCID 584658733-Bromo-7-iodo-5',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazin]-2'-amine

Product 1

HCID 584658843-Bromo-7-(2-fluoropyridin-3-yl)-5',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazin]-2'-amine

Sources & evidence

ORD record
ord-6587ada66ae547c3863d817ebb7ad50f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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