HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 4-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 4-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine | HCID 19693934 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine | HCID 19694031 | — |
Reaction Steps
1 g of 4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine is stirred with 20 ml of formic acid and 5 ml of acetone for 5 hours. The residue which remains after concentrating is purified by chromatography on silica gel using ethyl acetate. 0.3 g=41%; m.p.: 56° to 57° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723450 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-91ac38e1cd644fcdbb0f2037b7004087 |
| Source note | uspto-grants-1998_03 |