HCID 602709, compound → HCID 22039032, compound
Reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:12][OH:13])[CH:7]=[C:8]([CH2:10][OH:11])[CH:9]=1)[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[C:8]([CH2:10][OH:11])[CH:9]=1)[CH:12]=[O:13])[CH3:2]Participants
4
Reagents, catalysts & solvents 2
Procedure
MnO2 (8.37 g, 96.3 mmol) was added to a solution of (3-ethoxy-5-hydroxymethyl-phenyl)-methanol (17.55 g, 96.3 mmol) in CH2Cl2 (175 ml) and the mixture was stirred for 64 h. at room temperature. Thereafter, further MnO2 (8.37 g, 96.3 mmol) was added and the mixture was stirred for 6 h. The mixture was filtered over Celite and the filtrate was concentrated. The product was purified by chromatography. There were obtained 8.32 g (48%) of 3-ethoxy-5-hydroxymethyl-benzaldehyde as a colorless oil.
Workup
- stirringthe mixture was stirred for 6 h
- filtrationThe mixture was filtered over Celite
- concentrationthe filtrate was concentrated
- customThe product was purified by chromatography
Sources & evidence
- ORD record
- ord-c50574a75bc5446180dda64a4ff316fd
- Source dataset
- uspto-grants-2002_11
- Patent number
- US06476264B2
Reaction notes
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