3-Chlorophenylacetic acid → 2-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

HRID 1016835

Reaction equation

HRID 1016835 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476412-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

Procedure

Following General Procedure I′ above and using 3-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-e99b217c09ae451984c80bb9c9872c1f
Source dataset
uspto-grants-2002_11
Patent number
US06476263B1

Linked notes

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