Aluminum(III) Chloride → 4-Iodo-3-nitro-benzophenone

HRID 1017791

Reaction equation

HRID 1017791 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[Cl-].[Cl-].[Cl-].[Al+3]>C1C=CC=CC=1>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([C:2]2[CH:10]=[CH:9][CH:5]=[CH:4][CH:3]=2)=[O:8])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 112085984-Iodo-3-nitrobenzoic acid

Product 1

HCID 111873024-Iodo-3-nitro-benzophenone

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

5.3 g (17 mmol) of 4-iodo-3-nitrobenzoic acid and 8.0 g (60 mmol) of aluminium trichloride are added successively to 70 ml of benzene while cooling with an ice bath. Then the mixture is stirred for 2 hours at ambient temperature, then poured into ice water, extracted with methylene chloride, dried with sodium sulphate and concentrated in vacuo.

Workup

  1. temperaturewhile cooling with an ice bath
  2. extractionextracted with methylene chloride
  3. dry with materialdried with sodium sulphate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2af6b35e3597405292621887034b7779
Source dataset
uspto-grants-2002_11
Patent number
US06479524B1

Linked notes

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