Water → 4-Bromo-3,5-dichloroaniline
Reaction equation
[Br:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9]C(=O)C)=[CH:4][C:3]=1[Cl:13].[OH-].[Na+].O>C(O)CO>[Br:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH2:9])=[CH:4][C:3]=1[Cl:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
202 g of N-(4-bromo-3,5-dichlorophenyl)acetamide and 220 g of sodium hydroxide (as an aqueous 50% solution) in 670 ml of ethylene glycol are stirred for 5 hours at 120° C. and then for 12 hours at room temperature. 3000 ml of water are added, the mixture is filtered, the organic phase is dried over magnesium sulphate and the solvents are evaporated off under reduced pressure. The residue obtained is crystallized from cyclohexane; m.p.=132° C.
Workup
- filtrationthe mixture is filtered
- dry with materialthe organic phase is dried over magnesium sulphate
- customthe solvents are evaporated off under reduced pressure
- customThe residue obtained
- customis crystallized from cyclohexane
Sources & evidence
- ORD record
- ord-83453a3d41ff4b13af18e9402edbacd6
- Source dataset
- uspto-grants-2002_11
- Patent number
- US06482986B1
Reaction notes
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