4-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine → 4-Methoxy-2-(pyrrolidin-1-yl)-5-aminopyridine

HRID 1019558

Reaction equation

HRID 1019558 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][N:6]=[C:5]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:4]=1>[Pd]>[NH2:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][C:5]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 574315184-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine

Product 1

HCID 574315194-Methoxy-2-(pyrrolidin-1-yl)-5-aminopyridineYield 96.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The method described in Stage 12.2 is followed, starting from 1.5 g (6.72 mmol) of 4-methoxy-5-nitro-2-(pyrrolidin-1-yl)-pyridine, obtained in Stage 6.1, and 0.15 g of palladium on charcoal at 10%. We thus obtain 1.25 g of the expected product.

Sources & evidence

ORD record
ord-d364502db64e4717960a377a22893ca1
Source dataset
uspto-grants-2014_05
Patent number
US08716272B2

Linked notes

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