(Z)-Prop-1-en-1-ylboronic acid → HCID 178439561, compound

HRID 1019721Notes

Reaction equation

HRID 1019721 reaction equation
Br[C:2]1[N:7]=[C:6]2[N:8]([CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[C:9]([OH:11])=[N:10][C:5]2=[N:4][CH:3]=1.[CH:17](/B(O)O)=[CH:18]/[CH3:19]>>[CH3:14][CH2:13][CH:12]([N:8]1[C:6]2=[N:7][C:2](/[CH:17]=[CH:18]\[CH3:19])=[CH:3][N:4]=[C:5]2[N:10]=[C:9]1[OH:11])[CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 5355539(Z)-Prop-1-en-1-ylboronic acidHCID 178446210HCID 178446210, compound

Product 1

HCID 178439561HCID 178439561, compound

Procedure

The title compound was prepared by reacting 6-bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol (1.0 equiv), (Z)-prop-1-enyl boronic acid (1.5 equiv) and (DPPF)PdCl2 (0.15 equiv) in a manner analagous to Example 1(d). LCMS m/z (APCI)=247.0 (M+H).

Sources & evidence

ORD record
ord-aebb35aa6ca24470b92635b08d97224f
Source dataset
uspto-grants-2014_05
Patent number
US08716291B2

Reaction notes

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