Hydrogen chloride-ethyl acetate → HCID 66975500, compound
Reaction equation
[C:1]([N:4]([CH2:6][C@H:7]1[C@H:13]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[O:12][CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)[CH3:5])(=[O:3])[CH3:2].C(OCC)(=O)C.Cl>>[ClH:20].[Cl:21][C:16]1[CH:15]=[C:14]([C@@H:13]2[O:12][CH2:11][CH2:10][NH:9][CH2:8][C@H:7]2[CH2:6][N:4]([CH3:5])[C:1](=[O:3])[CH3:2])[CH:19]=[CH:18][C:17]=1[Cl:20]Participants
3
Procedure
To tert-butyl (6R,7R)-6-{[acetyl(methyl)amino]methyl}-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (100 mg) was added 4.0 M hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 1 hr. The residue obtained by concentration under reduced pressure was separated by HPLC (C18, mobile phase: water/acetonitrile (containing 10 mM NH4HCO3)), and the obtained fraction was concentrated under reduced pressure to give the title compound (60 mg).
Workup
- customThe residue obtained by concentration under reduced pressure
- customwas separated by HPLC (C18, mobile phase: water/acetonitrile (containing 10 mM NH4HCO3))