Phenoxyacetic Acid → HCID 66975883, compound

Reaction equation

[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[O:25]([CH2:32][C:33](O)=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:33](=[O:34])[CH2:32][O:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

Reactant 2

HCID 19188Phenoxyacetic Acid

HCID 66975351HCID 66975351, compound

Product 1

HCID 66975883HCID 66975883, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate and 2-phenoxyacetic acid, and in the same manner as in Example 39, the title compound was obtained.

Sources & evidence

ORD record: ord-4428000b43df4e31a9a8b13f11d08ad5
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722662B2

Reaction notes

Loading…