Methyl 2-oxo-1,2-dihydropyridine-3-carboxylate → HCID 66975891, compound
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C@H:9]2[CH2:22][O:23]S(C)(=O)=O)=[CH:4][C:3]=1[F:28].O=[C:30]1[C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=[CH:32][NH:31]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[O:14][CH2:13][CH2:12][NH:11][CH2:10][C@H:9]2[CH2:22][O:23][C:30]2[C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=[CH:32][N:31]=2)=[CH:4][C:3]=1[F:28]Participants
3
Procedure
Using tert-butyl (6S,7R)-7-(4-chloro-3-fluorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate and methyl 2-oxo-1,2-dihydropyridine-3-carboxylate, and by a method similar to that in Example 31, steps C and E, the title compound was obtained.
Sources & evidence
- ORD record
- ord-24220283c95740ceb8854069d556ee1c
- Source dataset
- uspto-grants-2014_05