Ethane, isocyano- → (2S,3S)-3-Amino-N-ethyl-2-hydroxypentanamide dihydrochloride

HRID 1025314

Reaction equation

HRID 1025314 reaction equation
[ClH:1].Cl.[NH2:3][C@@H:4]([CH2:13][CH3:14])[C@H:5]([OH:12])[C:6]([NH:8][CH:9]1C[CH2:10]1)=[O:7].[N+](CC)#[C-]>>[ClH:1].[ClH:1].[NH2:3][C@@H:4]([CH2:13][CH3:14])[C@H:5]([OH:12])[C:6]([NH:8][CH2:9][CH3:10])=[O:7]

Participants

3

Reactant 2

HCID 12226Ethane, isocyano-HCID 86762404(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

Product 1

HCID 86762423(2S,3S)-3-Amino-N-ethyl-2-hydroxypentanamide dihydrochloride

Procedure

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride, Representative Procedure A, using isocyanoethane in the third step (A3).

Sources & evidence

ORD record
ord-fc4f21ab3aaf4677829ff739de06fa3f
Source dataset
uspto-grants-2014_05
Patent number
US08729061B2

Linked notes

Loading…