(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-bromo-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

HRID 1025982

Reaction equation

HRID 1025982 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:14]([OH:16])=O)[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[F:17][C:18]([F:27])([F:26])[C:19]1[N:23]=[C:22]([CH2:24][NH2:25])[O:21][N:20]=1>>[Br:1][C:2]1[C:7]([O:8][CH2:9][C:10]([F:11])([F:12])[F:13])=[N:6][CH:5]=[C:4]([CH:3]=1)[C:14]([NH:25][CH2:24][C:22]1[O:21][N:20]=[C:19]([C:18]([F:27])([F:26])[F:17])[N:23]=1)=[O:16]

Participants

3

Reactant 2

HCID 55263061(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 581925925-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 866631435-bromo-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 97%, 448.9532 (M−H)−.

Sources & evidence

ORD record
ord-0ea2edd16e1d4789ac75c8d60c20e58b
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Linked notes

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